In 1994 he moved to Las Vegas, Nevada where he sought out high stakes poker games.
Lederer is known as "The Professor" because of his demeanor, analytical style and long history of wins. He has made an instructional poker video called Secrets of No Limit Hold'em and he runs the Howard Lederer Poker Fantasy Camp. He also co-hosts Poker Superstars and Poker: Learn from the Pros for the Fox Broadcasting Company.
Lederer is known for his focused, calm demeanor at the poker table; he has stated that he has applied zen wisdom to his poker playing. However, in 2002, Lederer publicly criticized Daniel Negreanu for making inappropriate comments about Duke. Negreanu later apologized and the two are known to be good friends. Also, at the World Poker Tour Grand Prix de Paris 2003, Lederer refused to shake hands with notorious needler Tony G when eliminated from the tournament.
As of 2008, his total live tournament winnings exceed $4,800,000. He has won two World Series of Poker bracelets and two World Poker Tour titles.